Expert services like Morningstar and The Motley Fool have identified these as top picks for long-term holding. NASDAQ:NVDA

: Up 301% YTD as of April 2026. It is currently the top performer in the S&P 500, benefiting from soaring demand for NAND flash memory used in AI data centers.

Several companies have seen triple-digit gains in the first four months of 2026, often led by specialized healthcare breakthroughs or critical AI hardware components.

: Up over 267% YTD after reporting positive clinical data for its RAS/MAPK pathway-driven cancer treatments.

: Up roughly 394% YTD following the commercial launch of its cancer therapy, Anktiva, in Saudi Arabia and expansion into Europe.

: Up over 204% YTD following successful Phase 3 trials for its psoriasis therapy.

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