Because Apple transitioned to and removed 32-bit app support starting with macOS Catalina, standard "Wine 2.0" builds will not work on modern systems. You should look for "Wine CX" builds or tools like Whisky that handle the translation between Intel (x86) and Apple (ARM) architectures.
The release of Wine 2.0 was significant for Mac users because it introduced over 6,600 individual changes, focusing on better performance and compatibility. Wine for Mac 2.0
Improved scaling and rendering for high-resolution Retina displays, making Windows apps look less "blurry" on modern MacBooks. How to use Wine on Modern macOS Because Apple transitioned to and removed 32-bit app