The Masterminds are high-ranking Umbrella employees or associates, each with unique reasons for participating:
: A member of S.T.A.R.S. who experiences these experiments as "nightmares" that she eventually realizes are real. RESIDENT-EVIL-RESISTANCE.rar
: One of Umbrella's founders, searching for a viral mutation that grants immortality or superhuman abilities without physiological alteration. RESIDENT-EVIL-RESISTANCE.rar
: A firefighter who went missing while attempting to assist in the Raccoon City evacuation. RESIDENT-EVIL-RESISTANCE.rar