The narrative generally centers on a group of lifelong friends—often three or four women—who met in school and swore to be "ragazze per sempre." The story typically unfolds across two or three distinct timelines:

A major life event—a betrayal, a sudden loss, or a geographic move—that threatens to pull the group apart. In many Italian dramas with this title, this period explores how adult responsibilities like career and marriage test their childhood promises.

Overcoming domestic or social pressures, a theme recently explored in similar adaptations like the Netflix series Forever (2025).