: There are no common causes (confounders) shared between the genetic variants and the outcome.
MR uses genetic variants as "natural experiments" to determine if an exposure (like high blood pressure) truly causes a disease (like stroke), rather than just being associated with it. ⚖️ The Three Pillars of MR Validity Diseases - Mr Validity
This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more A Guide to Understanding Mendelian Randomization Studies : There are no common causes (confounders) shared
: The genetic variants affect the outcome only through the exposure, with no alternative biological pathways (a phenomenon known as horizontal pleiotropy). 📊 Key Components of an MR Study For medical advice or diagnosis, consult a professional
: Occurs if the chosen genetic variant is only weakly linked to the exposure, leading to inaccurate results.