Bmp4 <1080p>

: It typically suppresses "default" neural differentiation to promote skin formation; however, in the adult brain, it helps maintain neural stem cell pools. Metabolic & Clinical Significance

: It primarily signals through two routes: in the adult brain

: It initiates bone and cartilage development and is particularly critical for patterning teeth. Mutations in BMP4 are linked to tooth agenesis (missing teeth). in the adult brain

Beyond development, BMP4 is a major player in adult metabolism and disease. in the adult brain

BMP4 is essential from the earliest stages of life, where its loss often leads to embryonic lethality.