In the 19th and 20th centuries, it was famously known as the "Royal Disease." Queen Victoria was a carrier and passed the gene to various royal houses across Europe, including the ruling families of Spain, Germany, and Russia. The most famous case was Alexei Nikolaevich, the Tsar’s son, whose condition led the family to seek help from the mystic Rasputin, indirectly impacting the Russian Revolution. Types and Severity

Hemophilia is almost always inherited and is "X-linked." This means the gene responsible for the condition sits on the X chromosome.

There are two primary forms, depending on which protein is missing:

Since females have two X chromosomes (XX), a healthy gene on one can usually compensate for a faulty one on the other. The Royal Connection